Fatal liver injury associated with rifampin-pyrazinamide treatment of latent tuberculosis infection.

نویسندگان

  • Kenneth G Castro
  • John A Jereb
  • Venkatarama Rao Koppaka
  • David L Cohn
چکیده

1 Ohta Y, Ohta N, Tamura M, et al. Vascular endothelial growth factor expression in airways of patients with lung cancer: a possible diagnostic tool of responsive angiogenic status on the host side. Chest 2002; 121:1624–1627 2 Brock CS, Lee SM. Anti-angiogenic strategies and vascular targeting in the treatment of lung cancer. Eur Respir J 2002; 19:557–570 3 Herbst RS, Hidalgo M, Pierson AS, et al. Angiogenesis inhibitors in clinical development for lung cancer. Semin Oncol 2002; 29(suppl):66–77 4 Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 1990; 347:645–650 5 Kawahito Y, Kondo M, Tsubouchi Y, et al. 15-deoxy12, 14-PGJ2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats. J Clin Invest 2000; 106:189 –197 6 Inoue K, Kawahito Y, Tsubouchi Y, et al. Expression of peroxisome proliferator-activated receptor in renal cell carcinoma and growth inhibition by its agonists. Biochem Biophys Res Commun 2001; 287:727–732 7 Tsubouchi Y, Sano H, Kawahito Y, et al. Inhibition of human lung cancer cell growth by the peroxisome proliferatoractivated receptoragonists through induction of apoptosis. Biochem Biophys Res Commun 2000; 270:400–405 8 Inoue K, Kawahito Y, Tsubouchi Y, et al. Expression of peroxisome proliferator-activated receptor (PPAR)in human lung cancer. Anticancer Res 2001; 21:2471–2476 9 Xin X, Yang S, Kowalski J, et al. Peroxisome proliferatoractivated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo. J Biol Chem 1999; 274: 91116–91121 10 Sano H, Hla T, Maier JAM, et al. In vitro cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. Clin Invest 1992; 89:97–108

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منابع مشابه

Fatal and severe hepatitis associated with rifampin and pyrazinamide for the treatment of latent tuberculosis infection--New York and Georgia, 2000.

One of the recommended treatments for latent tuberculosis infection (LTBI) is a 9-month regimen of isoniazid (INH); a 2-month regimen of rifampin (RIF) and pyrazinamide (PZA) is an alternative in some instances. In September 2000, a man in New York died of hepatitis after 5 weeks of RIF-PZA, and in December, a woman in Georgia was admitted to a hospital because of hepatitis after 7 weeks of thi...

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Short-course rifampin and pyrazinamide compared with isoniazid for latent tuberculosis infection: a multicenter clinical trial.

BACKGROUND Rifampin and pyrazinamide are recommended for treatment of latent tuberculosis infection in adults without HIV infection, but reports of severe hepatotoxicity have raised concerns about its safety. Clinical trials have not compared this treatment with isoniazid in adults without HIV infection. OBJECTIVE To compare the safety and tolerance of a 2-month regimen of rifampin and pyrazi...

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Severe or fatal liver injury in 50 patients in the United States taking rifampin and pyrazinamide for latent tuberculosis infection.

BACKGROUND Severe liver injuries were attributed to the rifampin and pyrazinamide (RZ) regimen after it was recommended for treating latent tuberculosis infection. Implicating RZ as the likeliest cause required excluding alternative causes. METHODS US health departments reported data on patients who died or were hospitalized for liver disease within 1 month after taking RZ for latent tubercul...

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Death associated with rifampin and pyrazinamide 2-month treatment of latent mycobacterium tuberculosis.

We present the case of an elderly patient who died of fulminant hepatic failure in the course of receiving 2 months of treatment with pyrazinamide and rifampin for his latent tuberculosis. This 2-month course of treatment for latent tuberculosis is one of four options recently recommended by the Centers for Disease Control and Prevention. We discuss the safety of using this two-drug regimen to ...

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Latent tuberculosis: revised treatment guidelines.

ing to 1999 estimates, 1.86 billion people — one third of the world’s population — are infected with tuberculosis. Most people with primary tuberculosis (TB) do not have signs or symptoms and may not know that they are infected. Their immune systems contain the tubercle bacilli in oxygen-deprived small granulomas, where the bacilli lie dormant for years. Following primary infection, the lifetim...

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Use of intermittent rifampin and pyrazinamide therapy for latent tuberculosis infection in a targeted tuberculin testing program.

BACKGROUND To determine the rates of hepatotoxicity and treatment completion associated with intermittent rifampin and pyrazinamide (RZ) therapy for latent tuberculosis infection, we evaluated a cohort of patients from a targeted tuberculin testing site in Tennessee. METHODS From 4 February 2000 through 9 November 2001, a total of 423 patients with latent tuberculosis infection received direc...

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عنوان ژورنال:
  • Chest

دوره 123 3  شماره 

صفحات  -

تاریخ انتشار 2003